Methylenetetrahydrofolate Reductase <i>Gene rs1801131</i> and <i>rs1801133</i> Polymorphisms were Associated with Susceptibility to Coronary Artery Disease and Nonalcoholic Fatty Liver Disease
نویسندگان
چکیده
Background and objectivesMethylenetetrahydrofolate Reductase (MTHFR) is the critical enzyme in folate 1-carbon metabolism. MTHFR polymorphisms may result increased homocysteine levels, be associated with abnormal lipid metabolism liver. This study aims to explore association between gene of rs1801131 rs1801133 susceptibility nonalcoholic fatty liver disease (NAFLD) coronary artery (CAD).
منابع مشابه
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متن کاملMethylenetetrahydrofolate reductase mutation and coronary artery disease.
authors and five references. They should not have tables or figures and should relate solely to an article published in Circulation within the preceding 12 weeks. Only some letters will be published. Authors of those selected for publication will receive prepublication proofs, and authors of the article cited in the letter will be invited to reply. Replies must be signed by all authors listed i...
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BACKGROUND Hypermocysteinemia has been substantiated as a risk factor for occlusive vascular disease. A common mutation (nucleotide 677 C-->T) has been described recently in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene, which results in a valine for alanine substitution, a thermolabile enzyme, and a tendency to elevate plasma homocysteine levels and which has been proposed to contr...
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ژورنال
عنوان ژورنال: Gene Expression
سال: 2023
ISSN: ['1052-2166', '1555-3884']
DOI: https://doi.org/10.14218/ge.2022.00016s